1/16 
1 FC Porto v Manchester City FC
2 AFC Ajax v Manchester United FC
3 FC Lokomotiv Moskva v Athletic Club 
4 FC Salzburg v FC Metalist Kharkiv
5 Stoke City FC v Valencia CF
6 FC Rubin Kazan v Olympiacos FC
7 AZ Alkmaar v RSC Anderlecht 
8 S.S. Lazio v Club Atlético de Madrid
9 FC Steaua Bucuresti v FC Twente
10 FC Viktoria Plzen v FC Schalke 04
11 Wisla Kraków v R. Standard de Liège
12 SC Braga v Besiktas JK
13 Udinese Calcio v PAOK FC
14 Trabzonspor AS v PSV Eindhoven
15 Hannover 96 v Club Brugge KV
16 Legia Warszawa v Sporting Clube de Portugal

1/8
Salzburg/Metalist v Rubin/Olympiacos
Legia/Sporting v Porto/Manchester City
Steaua/Twente v Plzen/Schalke
Wisla/Standard v Hannover/Club Brugge
Stoke/Valencia v Trabzonspor/PSV
AZ/Anderlecht v Udinese/PAOK
Lazio/Atlético v Braga/Besiktas 
Ajax/Manchester United v Lokomotiv/Athletic

Källa: UEFA.com